Important Notes Human Health & Diseases:

Important Notes Human Health & Diseases: Diseases caused by Protozoa

1. Malaria

• Malaria is a life-threatening disease that’s typically transmitted through the bite of an infected Anopheles mosquito affecting humans and other animals caused by parasitic protozoan belonging to the Plasmodium type.
• There are four species of Plasmodium which causes four main types of malaria in human are: 

1. Plasmodium falciparum (Malignant tertian malaria)
2. Plasmodium malariae (Quartian malaria)
3. Plasmodium vivax (Benign tertian malaria)
4. Plasmodium ovate (Mild tertian malaria)

Life Cycle of Plasmodium:

The natural ecology of malaria involves malaria parasites infecting successively two types of hosts: humans and female Anopheles mosquitoes. In humans, the parasites grow and multiply first in the liver cells and then in the red cells of the blood. In the blood, successive broods of parasites grow inside the red cells and destroy them, releasing daughter parasites (“merozoites”) that continue the cycle by invading other red cells.

The blood stage parasites are those that cause the symptoms of malaria. When certain forms of blood stage parasites (“gametocytes”) are picked up by a female Anopheles mosquito during a blood meal, they start another, different cycle of growth and multiplication in the mosquito.

After 10-18 days, the parasites are found (as “sporozoites”) in the mosquito’s salivary glands. When the Anopheles mosquito takes a blood meal on another human, the sporozoites are injected with the mosquito’s saliva and start another human infection when they parasitize the liver cells.

Thus the mosquito carries the disease from one human to another (acting as a “vector”). Differently from the human host, the mosquito vector does not suffer from the presence of the parasites.

The malaria parasite life cycle involves two hosts. During a blood meal, a malaria-infected female Anopheles mosquito inoculates sporozoites into the human host  . Sporozoites infect liver cells  and mature into schizonts, which rupture and release merozoites . (Of note, in P. vivax and P. ovale a dormant stage [hypnozoites] can persist in the liver and cause relapses by invading the bloodstream weeks, or even years later.) After this initial replication in the liver (exo-erythrocytic schizogony ), the parasites undergo asexual multiplication in the erythrocytes (erythrocytic schizogony ). Merozoites infect red blood cells . The ring stage trophozoites mature into schizonts, which rupture releasing merozoites . Some parasites differentiate into sexual erythrocytic stages (gametocytes) . Blood stage parasites are responsible for the clinical manifestations of the disease. The gametocytes, male (microgametocytes) and female (macrogametocytes), are ingested by an Anopheles mosquito during a blood meal . The parasites’ multiplication in the mosquito is known as the sporogonic cycle . While in the mosquito’s stomach, the microgametes penetrate the macrogametes generating zygotes . The zygotes in turn become motile and elongated (ookinetes)  which invade the midgut wall of the mosquito where they develop into oocysts . The oocysts grow, rupture, and release sporozoites, which make their way to the mosquito’s salivary glands. Inoculation of the sporozoites  into a new human host perpetuates the malaria life cycle. 

Symptoms

Fever at intervals, sudden acute chilliness ( cold or rigor state) accompanied by shivering followed by rising in temperature. After 2-4 hours of fever, there is profuse sweating which lowers the body temperature to near norm 

Treatment

Treatment of Malaria includes drugs like Chloroquine & Quinine (derived from the bark of Cinchona tree) and adding Gambusia fishes to stagnant water

 20 August is observed as the Mosquito day or Malaria Day

2.  Amoebiasis (amoebic dysentery)

Diagnosis

• by microscopical detection of trophozoites or cysts in fecal smears.
• The presence of white, stone shaped 'Charcot-Leydon crystals' in feces suggest the E. histolytica infection 

Treatment

• For temporary relief, an alkaloid Emetine is effective.
• A synthetic derivative called Dehydroemetine is equally effective.
• The most significant advance in the treatment of amoebiasis has been the use of Metronidazole and Tinidazole as an amoebicide

3. Giardiasis ( Diarrhoea)

Caused by a zooflagellate protozoan which is the first human parasitic protozoan known, named Giardia intestinalis.

It lives in the upper parts (duodenum and jejunum) of human small intestine.

They grow and multiply through binary fission and absorbs nourishment from the food passing through the intestine.

A large number of parasites interfere with digestion and absorption of food.

Symptoms

This causes abdominal discomfort, diarrhea (watery and frequent

stools), epigastric pain, headache, and fever.

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